Séminaire - Nanoparticles-mediated magnetic and plasmonic tools for cancer therapy and tissue engineering, and the underlying corollary of the nanoparticles long-term biological fate - Claire Wilhelm

Lundi 30 novembre 2020 à 10 h 30

Visioconférence

Claire Wilhelm, chercheure - Laboratoire Matière et Systèmes Complexes (MSC), Université Paris Diderot

Abstract

Inorganic (magnetic and plasmonic) nanoparticles bring multiple assets to the biomedical field, for therapeutic and/or diagnostic approaches. I will show some of the recent applications that we explored, adopting the materials angle from the outset. In cancer therapy, we proposed combined and synergistic cancer solutions by applying multiple stimuli to the same nanoparticle. We also evidenced that intracellular endosomal confinement can dramatically decrease the heat delivered by magnetic hyperthermia, while it could be beneficial for photothermal therapy. In tissue engineering, we developed magnetic-based methods to manipulate living cells, towards the goal to provide purely cellular magnetic artificial tissue replacements, that can be stimulated on demand, for instance to induce magnetically (mechanically) stem cells differentiation. However, the use of nanoparticles for biomedical applications also raises more general issues of nanoparticles biosafety, once internalized in cells. We quantitatively monitored the fate of nanoparticles and their assimilation within a living tissue, we evidenced a massive biodegradation at the endosome site which can be protected by a gold or polymeric shell, and can also be the basis for the biosynthesis of bio-made nanoparticles anew.