Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Froux, L (Froux, Lionel)[ 1 ] ; Elbahnsi, A (Elbahnsi, Ahmad)[ 2 ] ; Boucherle, B (Boucherle, Benjamin)[ 3 ] ; Billet, A (Billet, Arnaud)[ 1 ] ; Baatallah, N (Baatallah, Nesrine)[ 4,5 ] ; Hoffmann, B (Hoffmann, Brice)[ 2,7 ] ; Alliot, J (Alliot, Julien)[ 3,8 ] ; Zelli, R (Zelli, Renaud)[ 3,9 ] ; Zeinyeh, W (Zeinyeh, Wael)[ 3,10 ] ; Haudecoeur, R (Haudecoeur, Romain)[ 3 ] ; Chevalier, B (Chevalier, Benoit)[ 4,5 ] ; Fortune, A (Fortune, Antoine)[ 3 ] ; Mirval, S (Mirval, Sandra)[ 1 ] ; Simard, C (Simard, Christophe)[ 1,11 ] ; Lehn, P (Lehn, Pierre)[ 6 ] ; Mornon, JP (Mornon, Jean-Paul)[ 2 ] ; Hinzpeter, A (Hinzpeter, Alexandre)[ 4,5 ] ; Becq, F (Becq, Frederic)[ 1 ] ; Callebaut, I (Callebaut, Isabelle)[ 2 ] ; Decout, JL (Decout, Jean-Luc)[ 3 ]
[ 1 ] Univ Poitiers, Lab Signalisat & Transports Ion Membranaires, F-86073 Poitiers, France
[ 2 ] Sorbonne Univ, Museum Natl Hist Nat, Inst Mineral Phys Mat & Cosmochim, IMPMC,CNRS,UMR 7590, F-75005 Paris, France
[ 3 ] Univ Grenoble Alpes, CNRS, DPM, F-38000 Grenoble, France
[ 4 ] Inst Necker Enfants Malades, INSERM, U1151, INEM, Paris, France
[ 5 ] Univ Paris, Paris, France
[ 6 ] Univ Bretagne Occidentale, INSERM, UMR1078, IBSAM, Brest, France
[ 7 ] Iktos, Paris, France
[ 8 ] Technol Servier, Orleans, France
[ 9 ] Inst Rech Clin Montreal, Montreal, PQ, Canada
[ 10 ] Univ Lyon 1, ISPB Fac Pharm, Lyon, France
[ 11 ] Univ Caen, Caen, France