Bioinfromatics and biophysics

We develop several approaches for protein sequence analysis, for cryo-EM images analysis and for the analysis of biomolecule dynamics. These have led, among others, to give useful tools for deciphering the structural and functional information within genomes, for predicting structural features associated with protein stability, for describing the conformational variability of macromolecular assemblies and for understanding the fundamental mechanisms associated with DNA damage. Specific developments are also made to develop therapeutic structure-based strategies based on peptides and small molecules design.

Selected publications:

T. Bitard-Feildel, I. Callebaut. Exploring the dark foldable proteome by considering hydrophobic amino acids topology. Sci. Rep. 7, 41425 (2017) (link)

M. Banach, N. Prudhomme, M. Carpentier, E. Duprat, N. Papandreou, B. Kalinowska, J. Chomilier, I. Roterman. Contribution to the prediction of the fold code: application to immunoglobulin and flavodoxin cases. PloS one, 10(4), p.e0125098 (2015) (link)

Q. Jin, C.O.S. Sorzano, J.M. de la Rosa-Trevín, J.R. Bilbao-Castro, R. Núñez-Ramírez, O. Llorca, F. Tama, S. Jonić. Iterative Elastic 3D-to-2D Alignment Method Using Normal Modes for Studying Structural Dynamics of Large Macromolecular Complexes. Structure 22, 496 (2014) (link)

P. López-Tarifa, M.-P. Gaigeot, R. Vuilleumier, I. Tavernelli, M. Alcamí, F. Martín,  M.-A. Hervé du Penhoat, M.-F. Politis. Ultrafast Damage Following Radiation-Induced Oxidation of Uracil in Aqueous Solution. Angew. Chem. Int. Ed. 52, 3160 (2013) (link) 

G. Faure, I. Callebaut. Comprehensive repertoire of foldable regions within whole genomes. PLoS Comput. Biol. 9, e1003280 (2013) (link)

Researchers:

Isabelle Callebaut, Jacques Chomilier, Elodie Duprat, Slavica Jonic, Jean-Paul Mornon, Marie-Anne Hervé du Penhoat, Fabio Pietrucci, Dirk Stratmann