Catherine Vénien-Bryan
Many signals in the cell are conveyed by interacting protein molecules. How do protein-protein interactions lead to a response? The most likely explanation is through changes in structure. We study protein-protein interactions in the control of signalling processes using electron microscopy and combining the results with information from X-ray diffraction and biophysical studies.
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POSITION
PU UPMC
CONTACT
Institut de Minéralogie, de Physique des Matériaux et de Cosmochimie
UPMC-Sorbonne Université, CNRS, IRD and MNHN
4, place Jussieu, 75005 Paris, France
E-mail: catherine.venien-bryan(at)upmc.fr
Research experience and positions held
2009-2012 Invited professor at the university of Oxford, Biochemistry Department
2009- : Professor UPMC, Paris
2001- 2009: Senior University Research Lecturer Biochemistry Department University of Oxford, Oxford,UK
1998-2001: Visiting Research Fellow Biochemistry Department University of Oxford, Oxford, UK
1993-1998: Lecturer in Biophysics University J. Fourier Grenoble, France
1991-1993: Post-doctoral research assistant Biochemistry Department University of
Oxford Oxford, UK, EC Bridge and Welcome Trust fellowships
1988-1990: Post-doctoral research assistant EMBL Heidelberg Germany (Structural Biology Program) DFG and EMBO fellowships
Academic Resume
-Habilitation à diriger des recherches (HDR) 1998
-PhD in Biophysics University Pierre et Marie Curie Paris6 1988
Publications
Vénien-Bryan C, Fernandes CAH. Overview of Membrane Protein Sample Preparation for Single-Particle Cryo-Electron Microscopy Analysis. Int. J. Mol. Sci. (2023) 24(19), 14785 (See article)
Fernandes CAH, Zuniga D, Fagnen C, Kugler V, Scala R, Péhau-Arnaudet G, Wagner R, Perahia D, Bendahhou S, Vénien-Bryan C. Cryo-electron microscopy unveils unique structural features of the human Kir2.1 channel. Science Advances (2022) 8:eabq8489 (See article)
Fagnen C, Bannwarth L, Oubella I, Zuniga D, Haouz A, Forest E, Scala R, Bendahhou S, De Zorzi R, Perahia D, Vénien-Bryan C. Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain. Int. J. Mol. Sci. (2021) 23(1):335 (See article)
Fagnen C, Bannwarth L, Zuniga D, Oubella I, De Zorzi R, Forest E, Scala R, Guilbault S, Bendahhou S, Perahia D, Vénien-Bryan C. Unexpected Gating Behaviour of an Engineered Potassium Channel Kir. Front. Mol Biosci. (2021) 8:691901 (See article)
Yang D, Wan X, Dennis AT, Bektik E, Wang Z, Costa MGS, Fagnen C, Vénien-Bryan C, Xu X, Gratz DH, Hund TJ, Mohler PJ, Laurita KR, Deschênes I, Fu JD. MicroRNA Biophysically Modulates Cardiac Action Potential via Directly Binding to Ion Channel. Circulation (2021) 43(16):1597-1613 (See article)
Fagnen C, Bannwarth L, Oubella I, Forest E, De Zorzi R, Araujo A, Mhoumadi Y, Bendahhou S, Perahia D, Vénien-Bryan C. New Structural insights into Kir channel gating from molecular simulations, HDX-MS and functional studies. Scientific Reports (2020) 10(1):8392 (See article)
Costa MGS, Fagnen C, Vénien-Bryan C, Perahia D. A New Strategy for Atomic Flexible Fitting in Cryo-EM Maps by Molecular Dynamics with Excited Normal Modes (MDeNM-EMfit). J. Chem. Inf. Model. (2020) 60(5): 2419–2423 (See article)
Liang, CC Li Z, Lopez-Martinez, Nicholson W, Vénien-Bryan C, Cohn M. The FANCD2-FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2. Nature Commun (2016) 7:12124 (2016) (See article)
De Zorzi R, Nicholson WV, Guigner JM, Erne-Brand F, Vénien-Bryan C. Growth of large and highly ordered 2D crystals of a K+ channel, structural role of lipidic environment. Biophys. J. 2013 105 :398-408 (See article)
Bavro VN, De Zorzi R, Schmidt MR, Muniz JR, Zubcevic L, Sansom MSP, Vénien-Bryan C, Tucker SJ X-ray Crystal structure of a KirBac potassium channel highlights a mechanism of channel opening at the bundlecrossing gate. Nature Structural & Molecular Biology (2012) 19(2) 158-63 (See article)
Sinclair J, Davies KM, Vénien-Bryan C, Noble M: Generation of protein lattices by fusing proteins with matching rotational symmetry . Nature Nanotechnology 2011.6(9):558-62 (See article)
Crozat E, Meglio A, Allemand JF, Chivers CE, Howarth M, Venien-Bryan C, Grainge I, Sherratt DJ. Separating speed and ability to displace roadblocks during DNA translocation by FtsK. Embo Journal 2010, 29:1423-1433. (See article)
Luik P, Chew C, Aittoniemi J, Chang J, Wentworth P, Dwek RA, Biggin PC, Vénien-Bryan C, Zitzmann N: The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy. Proc Natl Acad Sci U S A; 2009, 106 :12712-12716. (See article)
Vénien-Bryan C, Jonic S, Skamnaki V, Brown N, Bischler N, Oikonomakos NG, Boisset N, Johnson LN. The structure of phosphorylase kinase holoenzyme at 9.9 a resolution and location of the catalytic subunit and themsubstrate glycogen phosphorylase. Structure 2009, 17:117-127 (See article)
Jonic S, Vénien-Bryan C. Protein structure determination by electron cryo-microscopy Curr Opin Pharmacol. 2009;9(5):636-42 (See article)
Kuo AL, Domene C, Johnson LN, Doyle DA, Venien-Bryan Two different conformational states of the KirBac3.1 potassium channel revealed by electron crystallography. Structure 2005, 13:1463- 1472. (See article)
Passmore LA, Booth CR, Venien-Bryan C, Ludtke SJ, Fioretto C, Johnson LN, Chiu W, Barford D Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation. Molecular Cell 2005, 20:855-866. (See article)
Learning Societes
Vice-president of the Societé Française des Microscopies(2022)
President of the Societé Française des Microscopies (2020-2021)
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Institut de minéralogie, de physique des matériaux et de cosmochimie - UMR 7590
Sorbonne Université - 4, place Jussieu - BC 115 - 75252 Paris Cedex 5
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