Séminaire/Seminar - Greener, more selective analysis methods for trace compounds in complex samples - Valérie Pichon

Vendredi 4 octobre 2024 à 11 h
IMPMC - Sorbonne Université - 4 place Jussieu - 75005 Paris - Barre 22-23, 4e étage, salle 401
Valérie Pichon - Laboratoire Sciences Analytiques, Bioanalytiques et Miniaturisation
Sorbonne Université
Séminaire IMPMC vendredi 4 Octobre 2024, 11h
Greener, more selective analysis methods for trace
compounds in complex samples
Abstract
Developments in chromatography and mass spectrometry instrumentation have led to a real improvement in sensitivity and a reduction in analysis time. However, the analysis of trace or ultra-trace compounds from complex samples often requires a purification and pre-concentration step prior to chromatographic analysis. Liquid-liquid extraction and solid-phase extraction are the most widely used pre-treatment techniques for extracting molecules of interest from liquid samples, or for purifying extracts from solid samples.
However, despite their efficiency, these two methods still suffer from the fact that they
require a large quantity of solvent in relation to the sample size, and also lack selectivity for ultra-trace analysis of targeted analytes. Solvent consumption can be reduced by miniaturizing the extraction device. In addition, the use of solvents that are more environmentally friendly than conventional organic solvents can also limit the impact of the method in terms of sustainability.
With regard to the lack of selectivity of extraction methods, carriers implementing a
molecular recognition mechanism can be developed. These include immunosorbents
based on the use of antibodies specific to the molecule(s) of interest, oligosorbents based on the use of aptamers (i.e. sequence-specific oligonucleotides capable of binding a given molecule or ion with the same affinity as antibodies), and molecularly or ionically imprinted polymers, the synthesis of which leads to the formation of specific cavities mimicking the antibody recognition site, are three types of support that can improve the selectivity of the extraction procedure.
Their miniaturization and in-line coupling with nanoLC also contribute significantly to
reducing solvent consumption. Several applications on real samples will be presented to illustrate the enormous potential of these tools applied to complex samples of just 50-150 nL.
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Institut de minéralogie, de physique des matériaux et de cosmochimie - UMR 7590
Sorbonne Université - 4, place Jussieu - BC 115 - 75252 Paris Cedex 5
Adresse physique
Institut de minéralogie, de physique des matériaux et de cosmochimie - UMR 7590 - Sorbonne Université - 4, place Jussieu - Tour 23 - Barre 22-23, 4e étage - 75252 Paris Cedex 5
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